Agpeg Plus Esse

Macrogol 3350 and Simethicone-based product for bowel cleansing.



Agpeg plus esse is a medical device to be taken to achieve a complete bowel cleansing. Removal of solid debris in the colon is essential in preparation for endoscopic, radiological and ultrasound examinations for an accurate diagnosis.
Agpeg plus esse contains macrogol 3350, an inert substance that is not absorbed, does not irritate the mucosa, does not ferment and is eliminated in an unmodified form. Thanks to its affinity for water, it retains a high amount of fluids in the intestinal compartment, hydrating the fecal mass and stimulating peristalsis. It also contains simethicone, with anti-foaming action, which facilitates the elimination of gas in the gastrointestinal tract.
Therapeutic category
Product for oral administration.


Pack size: 4 sachet of 60.98g of macrogol 3350 and simethicone.


How to use
For a complete cleansing of the intestine, necessary for the preparation for some diagnostic tests (endoscopic or radiological examinations on the large intestine, abdominal ultrasounds) and in other clinical conditions, scrupulously follow the information provided by the center where the endoscopic examination is carried out, which they usually provide for a controlled dietary regime in the days preceding the exam.
The following doses apply, unless otherwise prescribed by a doctor. For the extemporaneous preparation of the oral solution:
1) pour the contents of 2 sachets into 1 L of water, shake well and drink the homogeneous solution within 1-2 hours, possibly taking 250 ml of solution every 10-15 minutes;
2) integrate with a further 500 ml (half a liter) of water until a total of 1.5 L is taken (1 L of Agpeg plus esse and 500 ml of water);
3) after about 1 hour, repeat the preparation with 2 other sachets and take the second liter of solution (and the additional 500 ml of water) in the same way.
After taking the first liter you will begin to feel bowel movements and urge to evacuate. The evacuations will be gradually more liquid until the emission of discharges of clear liquid without fecal residues. This indicates that the cleaning has been carried out correctly and you are ready to carry out the examination.
Do not take Agpeg plus esse in case of known hypersensitivity to macrogol or the other components, perforation, intestinal obstruction or stenosis, paralytic ileus, severe inflammatory diseases of the intestinal tract such as Crohn’s disease, ulcerative colitis and toxic megacolon. The use of laxatives is contraindicated in case of acute abdominal pain or of unknown origin, nausea and vomiting, rectal bleeding of unknown origin and in case of severe dehydration.
The product can reduce the residence time in the intestine and therefore the absorption of drugs administered simultaneously orally. It is therefore advisable, after taking a medicine, to let an interval of at least 2 hours elapse before taking Agpeg plus esse. Simethicone can interfere with the effect of some reagents used in diagnostics, such as guaiac gum. If you are taking medication for heart diseases, diabetes, epilepsy and in particular anticoagulants, antiplatelet drugs, hypotensive drugs, diuretics, non-steroidal anti-inflammatory drugs, laxatives, consult your doctor or the center where the examination will be carried out for a possible change in dosage. In any case, consult your doctor before taking Agpeg plus esse if you are undergoing other treatment.
Undesirable effects
Nausea, vomiting and gastrointestinal disorders (abdominal pain, borborigmi, diarrhea, sense of swelling) may occur; if the symptoms become intense it is necessary to take the product more slowly. Rare cases of allergic reactions (skin rash, hives, itching) have been reported: in this case, stop using the product and inform your doctor. In case of undesired reactions, even if different from those listed, stop the treatment and consult your doctor.
The oral solution must be prepared at the time of consumption. If you do not take it immediately, the solution should be stored in the refrigerator and in any case used within 24 hours. Do not add other ingredients to the solution. Do not use on patients weighing less than 20 kg or patients under 2 years. Only use the product in pediatric children, in pregnancy and during breast feeding after seeking medical advice. Keep the product or solution out of the reach of children. In patients with dysphagia who take starch-based thickeners, the possible interactions involving macrogol, which may reduce its thickening effect, must be considered. The product should only be used under strict medical supervision if there is a clinical history of hyponatremia or if there are conditions that may increase the risk of hyponatremia (renal, cardiovascular, hepatic diseases, use of diuretics, geriatric age, etc.). The product does not contain salts. Consider supplementing with salts with your doctor in order to avoid electrolyte imbalances (hyponatremia). Report any relevant medical conditions to the doctor, particularly cardiovascular disease, dysphagia, gastroesophageal reflux, history of epilepsy or muscle convulsions, alcoholism, kidney disease, plasma electrolyte imbalances.
Storage conditions
Store in a cool, dry place at a temperature not exceeding 25 °C, in the original packaging. The expiry date shown refers to the product properly stored in unopened package. Do not use damaged packaging. Do not use the product after the expiry date indicated on the package and on the sachet. The product is disposable: do not use the sachets partially or open in unknown times, because this mode of use could lead to risks of product contamination.

It is a medical device 



Read carefully the warnings and the instructions for use.


Additional Information

One sachet contains: Macrogol 3350, simethicone. Excipients: silicon dioxide, flavor, sodic saccharin. Gluten free.