Agpeg Esse

Macrogol 3350-based product with laxative action. With simethicone.


  • Constipation treatment
  • Elimination of intestinal gas


Agpeg esse is a medical device indicated for the symptomatic treatment of constipation. It promotes peristalsis, helping to have adequate bowel evacuation, thus counteracting constipation and preventing the formation of fecal impaction. It also facilitates the elimination of intestinal gas by reducing the sensation of bloating and abdominal distension.
How it works
Macrogol is a water-soluble inert polymer with a high molecular weight that has the ability to bind to the water used for intake, retaining it in the stool. It determines a rehydration and softening of the fecal mass and facilitates its evacuation. It accelerates intestinal transit by promoting peristalsis. It is not absorbed or metabolized in the gastrointestinal tract and does not lead to hydro-electrolyte imbalances when taken with the indicated dose of liquid. Simethicone is a substance that has the ability to decrease the surface tension of the gas bubbles in the gastrointestinal tract, facilitating their expulsion.
Therapeutic category
Agpeg esse is presented as a powder for oral solution.


Pack size: sachet of 10g.


Reccomendation and dosage
Adults and children over 12 years of age ( >43 Kg).
– 1 to 4 sachets per day
The dose must be increased or decreased, depending on the individual response to treatment, in order to allow for regular evacuation of soft stools. The maximum dose needed does not normally exceed 4 sachets per day.
Dissolve the powder in water or other liquid (125ml per sachet) and take it immediately. It is advisable to administer the product in the morning if the minimum dose is to be taken (1 sachet per day). For larger doses, divide the intake between morning and evening.
Do not take Agpeg esse in case of known hypersensitivity to macrogol or the other components, intestinal perforation, obstruction or stenosis, paralytic ileus, severe inflammatory diseases of the intestinal tract such as Crohn’s disease, ulcerative colitis and toxic megacolon. The use of laxatives is contraindicated in case of acute abdominal pain or of unknown origin, nausea and vomiting, rectal bleeding of unknown origin and in case of severe dehydration.
Side effects
Certain gastrointestinal disturbances may occur (stomach pain, flatulence, bloating, nausea and fecal incontinence). Diarrhea is a secondary effect of taking excessive doses of Agpeg esse and can be avoided by decreasing the intake dose. Cases of hypersensitivity reactions (skin rash) have been reported rarely following the use of products containing macrogol. In this case, stop the treatment and consult your doctor.
Administration to children should be carried out under the direct supervision of an adult. As a precaution, consult your doctor before use in pregnancy and lactation. Do not use after the expiry date indicated on the package and on the sachet. Do not use if package is opened or damaged. Do not exceed the maximum daily dose.
The product is disposable: do not use the sachets partially or open at unknown times, as this method of use could lead to risks of product contamination. Keep the product or the solution obtained out of the reach of children. If you do not notice any improvement after 7 days of treatment, you should consult your doctor. The product can reduce the permanence in the intestine and therefore the absorption of medicinal products for oral use. It is advisable to consult your doctor in case of simultaneous intake of medicines for oral use, which in any case must be administered at a distance of at least 2 hours. In case of adverse reactions, even if different from those listed, stop the treatment and consult your doctor. In patients with dysphagia who take starch-based thickeners, it should be considered the possible interactions of macrogol, which may reduce its thickening effect.

Storage conditions
Store in a cool, dry place, away from light and away from heat sources. The expiry date indicated refers to the product correctly stored in an unopened package.

It is a medical device


Carefully read the warnings and instructions for use.

Additional Information

Macrogol, silicon dioxide, simethicone, sucralose. Gluten free.